Detailed Abstract
[E-poster]
[EP017] Effects of alcohol consumption on circulating lipid in fatty liver disease and Represent Potential cardio metabolic risk markers in Kathmandu
Surya ram DUWAL1, 2, Urusha MAHARJAN*1
1Biochemistry, Central diagnostic laboratory and research center, Nepal
2Kedarnath medical hall and health care center, Biochemistry, Nepal
Introduction : liver is the principal site for formation and clearance of lipoproteins in our body. Alcohol-induced fatty liver (steatosis) was believed to result from excessive generation of reducing equivalents from ethanol metabolism, thereby increasing fat accumulation. Liver disease is the greatest cause of death related to alcohol and a major public health problem especially in developing country. High alcohol consumption is a major cause of morbidity, yet alcohol is associated with both favorable and adverse effects on cardio metabolic risk markers.
Methods : After consent, the present study examined aged ≥ 35 years from Kathmandu between 2019-2020. Data on current drinking status, age, ethnic group, educational background, waist circumference, body mass index, blood pressure and lipid profile was measured. Baseline venous blood sample was collected aseptically according to WHO guidelines with various inclusion and exclusion criteria. Processing was done in central diagnostic laboratory and research center.
Results : Out of 780 patients 17% were female and 83% were male. Mean +SD of Age, BMI, Waist circumference, Hipcircumference, Waisthipratio, Blood pressure were 45.93+10.92, 29.41+2.98, 100.97+ 7.0,105.94+6.5, 0.94+0.1 and 132+12/83+17 respectively.TG/HDL-C ratio, LDL-C/HDL-C ratio, TG, cholesterol and lipid accumulation product significantly higher in drinkers than normal reference range. Majority were ethnic group with low socioeconomic and literate background.
Conclusions : Abnormalities in lipid profile are correlated with alcohol consumption, which calls for intervention strategies to prevent dyslipidemia and control risk factors for cardiovascular disease. Alcohol consumption is associated with a complex metabolic signature, including aberrations in multiple biomarkers for elevated cardio metabolic risk factors.
Methods : After consent, the present study examined aged ≥ 35 years from Kathmandu between 2019-2020. Data on current drinking status, age, ethnic group, educational background, waist circumference, body mass index, blood pressure and lipid profile was measured. Baseline venous blood sample was collected aseptically according to WHO guidelines with various inclusion and exclusion criteria. Processing was done in central diagnostic laboratory and research center.
Results : Out of 780 patients 17% were female and 83% were male. Mean +SD of Age, BMI, Waist circumference, Hipcircumference, Waisthipratio, Blood pressure were 45.93+10.92, 29.41+2.98, 100.97+ 7.0,105.94+6.5, 0.94+0.1 and 132+12/83+17 respectively.TG/HDL-C ratio, LDL-C/HDL-C ratio, TG, cholesterol and lipid accumulation product significantly higher in drinkers than normal reference range. Majority were ethnic group with low socioeconomic and literate background.
Conclusions : Abnormalities in lipid profile are correlated with alcohol consumption, which calls for intervention strategies to prevent dyslipidemia and control risk factors for cardiovascular disease. Alcohol consumption is associated with a complex metabolic signature, including aberrations in multiple biomarkers for elevated cardio metabolic risk factors.
SESSION
E-poster
E-Session 3/25 ~ 3/27 ALL DAY