Detailed Abstract
[Liver Oral Presentation 3]
[LV OP 3-4] The histological growth pattern and the clinico-metabolic characteristics accurately predict the outcome in patients undergoing surgery for colorectal liver metastases - Belgian Group for Digestive Oncology (BGDO)
Ali BOHLOK1, Ivan DURAN DERIJCKERE2, Hugues AZEMA1, Valerio LUCIDI3, Sophie VANKERCKHOVE1, Alain HENDLISZ4, Jean Luc VAN LAETHEM5, Serge GOLDMAN6, Patrick FLAMEN1, Denis LARSIMONT7, Pieter DEMETTER7, Luc DIRIX8, Peter VERMEULEN9, Vincent DONCKIER*1
1Surgical Oncology, Institut Jules Bordet, Universit?Libre de Bruxelles (ULB), Brussels, Belgium
2Nuclear Medicine, Institut Jules Bordet, Universit?Libre de Bruxelles (ULB), Brussels, Belgium
3Abdominal Surgery, H?ital Erasme, Universit?Libre de Bruxelles (ULB), Brussels, Belgium
4Digestive Oncology, Institut Jules Bordet, Universit?Libre de Bruxelles (ULB), Brussels, Belgium
5Hepato-Gastroenterology, , H?ital Erasme, Universit?Libre de Bruxelles (ULB), Brussels, Belgium
6Nuclear Medicine, H?ital Erasme, Universit?Libre de Bruxelles (ULB), Brussels, Belgium
7Pathology, Institut Jules Bordet, Universit?Libre de Bruxelles (ULB), Brussels, Belgium
8Translational Cancer Research Unit (CORE), Gasthuiszusters Antwerpen Hospitals, University of Antwerp, Wilrijk, Antwerp, Belgium
9Translational Cancer Research Unit, GZA Hospitals & CORE, MIPRO, University of Antwerp, Antwerp, Belgium
Introduction : Selection for surgery in patients with colorectal liver metastases (CRLM) remains poorly personalized. We evaluated whether the combination of clinico-metabolic characteristics with the histological growth pattern (HGP) of CRLM could improve the prognostication in individual cases.
Methods : In a series of 108 patients undergoing resection of CRLM, the HGP of CRLM was scored according to international guidelines. A baseline metabolic-Clinical Risk Score (mCRS) was calculated by adding the 18FDG-PET/CT scan data as a parameter to the traditional Memorial Sloan Kettering CRS.
Results : In patients with desmoplastic HGP (DHGP) CRLM (20% of all patients), 5- and 10-years OS and DFS were 66% and 43% and 37% and 24.5%, as compared with 35% and 21% and 11% and 11% in the non-DHGP group (p=0.07 and 0.054). Among DHGP patients, those with a low-risk mCRS had significantly improved postoperative outcomes, 5- and 10-years OS and DFS reaching 83.3% and 62.5% and 50% and 33%, as compared with 18% and 0% and 0% and 0% in high-risk mCRS patients (p=0.007 and 0.003). In contrast, mCRS did not influence the postoperative survivals in non-DHGP patients.
Conclusions : Combining the clinico-metabolic characteristics with the HGP may improve prognostication in patients undergoing surgery for CRLM.
Methods : In a series of 108 patients undergoing resection of CRLM, the HGP of CRLM was scored according to international guidelines. A baseline metabolic-Clinical Risk Score (mCRS) was calculated by adding the 18FDG-PET/CT scan data as a parameter to the traditional Memorial Sloan Kettering CRS.
Results : In patients with desmoplastic HGP (DHGP) CRLM (20% of all patients), 5- and 10-years OS and DFS were 66% and 43% and 37% and 24.5%, as compared with 35% and 21% and 11% and 11% in the non-DHGP group (p=0.07 and 0.054). Among DHGP patients, those with a low-risk mCRS had significantly improved postoperative outcomes, 5- and 10-years OS and DFS reaching 83.3% and 62.5% and 50% and 33%, as compared with 18% and 0% and 0% and 0% in high-risk mCRS patients (p=0.007 and 0.003). In contrast, mCRS did not influence the postoperative survivals in non-DHGP patients.
Conclusions : Combining the clinico-metabolic characteristics with the HGP may improve prognostication in patients undergoing surgery for CRLM.
SESSION
Liver Oral Presentation 3
Room A 3/26/2021 8:21 AM - 8:28 AM