Detailed Abstract
[BP Oral Presentation 1]
[BP OP 1-5] Changes in total lymphocyte count and neutrophil-to-lymphocyte ratio after curative pancreatectomy in patients with pancreas adenocarcinoma and their prognostic role
Eun Young KIM1, Tae Ho HONG*2
1Division of Trauma and Surgical Critical Care, Department of Surgery, Seoul St. Mary’s Hospital, The Catholic University of Korea, Korea
2Division of Hepato-Biliary and Pancreas Surgery, Department of Surgery, Seoul St. Mary’s Hospital, The Catholic University of Korea, Korea
Introduction : To assess the prognostic significance of postoperative changes in immune status represented by total lymphocyte count (TLC) and neutrophil-to-lymphocyte ratio (NLR) in resectable pancreatic cancer.
Methods : Patients who underwent curative pancreatectomy for pancreatic adenocarcinoma were divided into high and low groups according to cut-off values of TLC, and NLR measured preoperatively, immediately after surgery, and 1- or 6-month after surgery. Oncologic outcomes were compared between the two groups at different times, and prognostic roles of TLC and NLR were evaluated.
Results : Of 193 patients, the median follow-up time was 22 months, and median survival was 18 months. Their immunologic status deteriorated within 3-4 days after the operation and recovered after that. At 1- and 6-month postoperatively, overall survival rates were significantly lower in the group with high NLR (>2.535 and >3.21, respectively) and low TLC (<1.66 ?109/L and <1.62 ?109/L, respectively). In multiple regression analysis, elevated NLR at postoperative 1- and 6-month and decreased TLC at postoperative 1-month were significant prognosis predictors.
Conclusions : Changes in immune status such as decreased TLC and elevated NLR at postoperative 1- and 6-month are effective prognostic predictors after curative pancreatectomy in patients with pancreatic adenocarcinoma.
Methods : Patients who underwent curative pancreatectomy for pancreatic adenocarcinoma were divided into high and low groups according to cut-off values of TLC, and NLR measured preoperatively, immediately after surgery, and 1- or 6-month after surgery. Oncologic outcomes were compared between the two groups at different times, and prognostic roles of TLC and NLR were evaluated.
Results : Of 193 patients, the median follow-up time was 22 months, and median survival was 18 months. Their immunologic status deteriorated within 3-4 days after the operation and recovered after that. At 1- and 6-month postoperatively, overall survival rates were significantly lower in the group with high NLR (>2.535 and >3.21, respectively) and low TLC (<1.66 ?109/L and <1.62 ?109/L, respectively). In multiple regression analysis, elevated NLR at postoperative 1- and 6-month and decreased TLC at postoperative 1-month were significant prognosis predictors.
Conclusions : Changes in immune status such as decreased TLC and elevated NLR at postoperative 1- and 6-month are effective prognostic predictors after curative pancreatectomy in patients with pancreatic adenocarcinoma.
SESSION
BP Oral Presentation 1
Room B 3/25/2021 12:08 PM - 12:15 PM