Detailed Abstract
[E-poster]
[EP041] Long-term oncologic outcomes of liver resection for hepatocellular carcinoma in adolescents and young adults: A multicenter study from a hepatitis B Virus-endemic area
Yong-Kang DIAO1, Jun-Wei LIU1, Wan Yee LAU3, Xin-Ping FAN4, Ting-Hao CHEN5, Ya-Hao ZHOU6, Wei-Min GU7, Hong WANG8, Jie LI9, Ying-Jian LIANG10, Tian YANG*1, 2
1Hepatobiliary Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital (People’s Hospital of Hangzhou Medical College), China
2Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Navy Medical University), China
3Faculty of Medicine, The Chinese University of Hong Kong, China
4General Surgery, Pingxiang Mining Group General Hospital, China
5General Surgery, Ziyang First People’s Hospital, China
6Hepatobiliary Surgery, Pu’er People’s Hospital, China
7General Surgery, The Fourth Hospital of Harbin, China
8General Surgery, Liuyang People’s Hospital, China
9Hepatobiliary Surgery, Fuyang People's Hospital, China
10Hepatobiliary Surgery, The First Affiliated Hospital of Harbin Medical University, China
Introduction : Hepatocellular carcinoma (HCC) is common among adolescents and young adults (AYAs) with chronic hepatitis B virus (HBV) infection in areas with endemic HBV. We sought to characterize clinical features and long-term oncologic outcomes among AYAs versus older adults (OAs) who underwent liver resection for HCC.
Methods : Patients undergoing curative-intent liver resection for HCC were identified using a Chinese multicenter database; patients were categorized as AYA (aged 13-39 years) versus OA (aged ≥ 40 years). Patient clinical features, perioperative outcomes, overall survival (OS) and time-to-recurrence (TTR) were evaluated and compared. Multivariable Cox-regression analyses were performed to identify the impact of age relative to the risk factors associated with OS and TTR.
Results : Among 1,952 patients with HCC who underwent resection, 354(22.2%) were AYAs. AYAs were less likely to have cirrhosis or portal hypertension yet were likely to have advanced tumor pathological characteristics than OAs. Although major hepatectomy was more often performed in the AYA group, postoperative morbidity and mortality were comparable between the AYA and OA groups. Compared with OAs, the AYAs had a comparable OS (median: 88.8 vs. 93.2 months, P=0.305) but a decreased TTR (median: 35.6 vs. 50.7 months, P=0.029). After adjustment for other confounding factors on multivariable analyses, young age (<40 years) was independently associated with poorer TTR (hazard ratio: 1.35, 95% confidence interval: 1.08-1.69, P=0.009) but not OS (P=0.15).
Conclusions : Compared with OAs, AYAs had a higher incidence of recurrence following liver resection among Chinese patients with HCC, suggesting that enhanced surveillance for postoperative recurrence may be required among
Methods : Patients undergoing curative-intent liver resection for HCC were identified using a Chinese multicenter database; patients were categorized as AYA (aged 13-39 years) versus OA (aged ≥ 40 years). Patient clinical features, perioperative outcomes, overall survival (OS) and time-to-recurrence (TTR) were evaluated and compared. Multivariable Cox-regression analyses were performed to identify the impact of age relative to the risk factors associated with OS and TTR.
Results : Among 1,952 patients with HCC who underwent resection, 354(22.2%) were AYAs. AYAs were less likely to have cirrhosis or portal hypertension yet were likely to have advanced tumor pathological characteristics than OAs. Although major hepatectomy was more often performed in the AYA group, postoperative morbidity and mortality were comparable between the AYA and OA groups. Compared with OAs, the AYAs had a comparable OS (median: 88.8 vs. 93.2 months, P=0.305) but a decreased TTR (median: 35.6 vs. 50.7 months, P=0.029). After adjustment for other confounding factors on multivariable analyses, young age (<40 years) was independently associated with poorer TTR (hazard ratio: 1.35, 95% confidence interval: 1.08-1.69, P=0.009) but not OS (P=0.15).
Conclusions : Compared with OAs, AYAs had a higher incidence of recurrence following liver resection among Chinese patients with HCC, suggesting that enhanced surveillance for postoperative recurrence may be required among
SESSION
E-poster
E-Session 3/25 ~ 3/27 ALL DAY