Detailed Abstract
[Poster Presentation]
[LV PP 3-6] Surgical Resection of Huge Hepatocellular Carcinoma. Prognostic Factors and Outcomes in a Mexican Cohort Study
Carlos FLOREZ-ZORRILLA*1, 2, 3, Karina MENDOZA-GALLO1
1HPB and Liver Transplant, Hospital Puerta de Hierro Andares Guadalajara, Mexico
2HPB and Liver Transplant, Hospital 햚geles Lomas Ciudad de M?ico, Mexico
3HPB and LIver Transplant, Centro M?ico ABC Ciudad de M?ico, Mexico
Introduction : Surgery is the best choice for curative treatment for hepatocellular carcinoma (HCC), that includes liver resection (LR) or liver transplantation (LT). Tumors larger than 10 cm are considered huge HCC. Huge HCC doesn큧 fit any criteria for LT. Although surgical resection may be associated with higher morbidity it큦 still the best chance of survival in this subgroup of patients. The purpose of our stydy is to analyze prognostic factors and outcomes in a mexican population.
Methods : We analyzed patients who underwent liver resection for huge HCC between january 2015 to january 2021. Prognostic factors included in the study were age, HCC size, serum alphafetoprotein (AFP) and vascular invasion. Only patients with Child–Pugh grade A in absence of extrahepatic disease was offered major liver resection. The future liver remnant volume was calculated by CT scan volumetry. Morbidity, disease free-survival and overall survival was evaluated.
Results : 52 patients underwent major liver resection: male 30 (57.6%) and female 22 (42.3%). The median age was 65 years (range 25 to 76 years), median HCC size was 16 cm (range 14 to 45 cm), median AFP was 85 ng/ml (range 18 to 19500 ng/ml). Lymphovascular invasion was found in 58% of liver specimens. The overall morbidity was 12% and perioperative mortality was seen in 1 (1.95) due to heart failure. The overall 1-year and 3-year survival were 88.4% and 51.9% respectively,
Conclusions : Factors of adverse outcome after major liver resection in patients with huge HCC were the presence of lymphovascular invasion, AFP 》 1000 , and age 》65 years.
Methods : We analyzed patients who underwent liver resection for huge HCC between january 2015 to january 2021. Prognostic factors included in the study were age, HCC size, serum alphafetoprotein (AFP) and vascular invasion. Only patients with Child–Pugh grade A in absence of extrahepatic disease was offered major liver resection. The future liver remnant volume was calculated by CT scan volumetry. Morbidity, disease free-survival and overall survival was evaluated.
Results : 52 patients underwent major liver resection: male 30 (57.6%) and female 22 (42.3%). The median age was 65 years (range 25 to 76 years), median HCC size was 16 cm (range 14 to 45 cm), median AFP was 85 ng/ml (range 18 to 19500 ng/ml). Lymphovascular invasion was found in 58% of liver specimens. The overall morbidity was 12% and perioperative mortality was seen in 1 (1.95) due to heart failure. The overall 1-year and 3-year survival were 88.4% and 51.9% respectively,
Conclusions : Factors of adverse outcome after major liver resection in patients with huge HCC were the presence of lymphovascular invasion, AFP 》 1000 , and age 》65 years.
SESSION
Poster Presentation
E-Session 3/25 ~ 3/27 ALL DAY