Detailed Abstract
[E-poster]
[EP053] Is liver resection still required for patients who have predictive factors for complete pathologic necrosis after downstaging for locally advanced hepatocellular carcinoma?
Munseok CHOI1, Gi Hong CHOI*1, Dai Hoon HAN1, Kyung Sik KIM1, Jin Sub CHOI1, Beom Kyung KIM2, Seung Up KIM2, Do Young KIM2, Jinsil SEONG3
1Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Yonsei University College of Medicine, Korea
2Department of Internal Medicine, Yonsei University College of Medicine, Korea
3Departments of Radiation Oncology, Yonsei University College of Medicine, Korea
Introduction : Liver resection is usually recommended in patients after downstaging for locally advanced hepatocellular carcinoma (HCC) to induce complete remission. However, the liver resection requirement in patients expected to have complete pathological necrosis (CPN) after HCC downstaging is questionable.
Methods : From 2002 to 2019, 919 patients with locally advanced HCC underwent concurrent chemoradiotherapy (CCRT) or transarterial radioembolization (TARE). Among these patients, excluding liver transplantation, 94 patients who underwent hepatic resection (OP group) and 789 patients who did not undergo surgical treatment (non-OP group) were included in this study. Predictive factors of CPN in the resected specimen after tumor downstaging in the OP group analyzed by logistic regression analysis.
Results : Of the 94 patients in the OP group, thirty-eight patients(40.4 %) were found to have CPN. In multivariable analysis, the predictive factors of CPN were complete radiologic response and tumor marker responder [Hazard ratio (HR) 1.00, p<0.006; HR 3.698, 95% confidence interval (CI) 1.029-13.321, p=0.045]. Among the non-OP group, 11 (%) patients belonged to the CPN-PF group. Of these patients, only two patients (18.2 %) have occurred intrahepatic recurrence. There was no difference in disease-free survival (DFS) between the CPN-PF group and the CPN group (119.0 ?77.42 vs. 60.00 ?14.04, p=0.075). In addition, the overall survival (OS) of the CPN-PF group was significantly higher than the OS of the CPN group (171.00 ?0.00 vs. 97.00 ?17.46, p=0.044).
Conclusions : This study showed that surgical resection might not provide further advantages for long-term outcomes in patients with CPN predictive factors after HCC downstaging.
Methods : From 2002 to 2019, 919 patients with locally advanced HCC underwent concurrent chemoradiotherapy (CCRT) or transarterial radioembolization (TARE). Among these patients, excluding liver transplantation, 94 patients who underwent hepatic resection (OP group) and 789 patients who did not undergo surgical treatment (non-OP group) were included in this study. Predictive factors of CPN in the resected specimen after tumor downstaging in the OP group analyzed by logistic regression analysis.
Results : Of the 94 patients in the OP group, thirty-eight patients(40.4 %) were found to have CPN. In multivariable analysis, the predictive factors of CPN were complete radiologic response and tumor marker responder [Hazard ratio (HR) 1.00, p<0.006; HR 3.698, 95% confidence interval (CI) 1.029-13.321, p=0.045]. Among the non-OP group, 11 (%) patients belonged to the CPN-PF group. Of these patients, only two patients (18.2 %) have occurred intrahepatic recurrence. There was no difference in disease-free survival (DFS) between the CPN-PF group and the CPN group (119.0 ?77.42 vs. 60.00 ?14.04, p=0.075). In addition, the overall survival (OS) of the CPN-PF group was significantly higher than the OS of the CPN group (171.00 ?0.00 vs. 97.00 ?17.46, p=0.044).
Conclusions : This study showed that surgical resection might not provide further advantages for long-term outcomes in patients with CPN predictive factors after HCC downstaging.
SESSION
E-poster
E-Session 3/25 ~ 3/27 ALL DAY